Risperdal for Aspergers Syndrome

Risperdal  (Risperidone) is an antipsychotic drug developed, tested, approved and used to treatment disorganized or psychotic thinking in adults. Extrapolating from use with adults, it is prescribed as an “ Off-Label” (not  FDA approved) use for Autistic Spectrum Disorders such as Aspergers Syndrome and Pervasive Developmental Disorders in children. For a discussion of the wisdom this extrapolation read
on this website. ADHD

Use with children:c

There is has been very little research on the use of Risperdal with children, and most of what there is has been withheld by the manufacturer.

Here is one publicly available study.

Risperidone (Risperdal) Tolerability in Children

Presented at the American Psychiatric Association, 2002 Annual Meeting

Hong Chen, M.D., Department of Psychiatry, Hershey Medical Center; Christopher A. Petersen, M.D.

Introduction: Little published data is available to determine the tolerability of Risperidone in children in an acute setting.

Method: In this prospective pilot study, hospitalized children (n = 10) with age range of 7 to 10 year, were administered Risperidone gradually to 0.04 mg/kg/day as clinically indicated and only if tolerated. Side effect rating scales were completed at baseline, within 24 hours of first dose to assess acute change, at 0.04mg/kg/day if possible to assess effects of therapeutic dosage, and prior to discharge. The average study period is 10 days.

Results: Among 10 hospitalized children with newly started on Risperidone, three (30%) developed mild degree of loss of appetite with one also had diarrhea, one (10%) developed mild rigidity, drooling, slurred speech within 24 hours of first dose, one(10%) had mild sedation. In terms of short term weight change by discharge, three (30%) children gained average weight of 0.9 kg, one (10%) lost 0.7 kg. Nine children were discharged on Risperidone without remaining problems of loss of appetite, diarrhea and sedation except weight change, and one child had to discontinue and switch to another neuroleptics.

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