The new study was conducted by Tim Kendall, deputy director of the Royal College of Psychiatrists' Research Unit in London, UK, and colleagues. One of Kendall's roles is to help analyse medical research to draw up the clinical guidelines on which the UK government bases its drug regulations.

After recent revelations that drug companies have suppressed unfavourable data on their drugs, Kendall and his colleagues contacted pharmaceutical companies requesting unpublished studies that might bear on the guidelines. None of the companies complied, so Kendall contacted a government agency which provided six unpublished studies on three anti-depressants known as selective serotonin reuptake inhibitors (SSRIs).

Kendall and his team added those results to a review of five published studies on the effects of various SSRIs on children.

"When we got the unpublished data and put it in with the published data, something happened. Instead of being safe and effective, the risk-benefit reversed," Kendall told New Scientist.

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