Wellbutrin is an atypical antidepressant that has been used to treat ADHD and Aspergers Syndrome..

Wellbutrin (bupropion) and Wellbutrin SR have been used in an off-label capacity (not specifically approved for, but observed to be effective) to treat ADHD and Aspergers Syndrome. Wellbutrin is also sold under the brand name Zyban to help stop the urge to smoke.

Wellbutrin has a chemical structure unrelated to any other antidepressant medication. Unlike some of the other recently developed antidepressants (i.e., Celexa, Paxil, Prozac, and Zoloft) that target the brain chemical serotonin, Wellbutrin does not affect serotonin. Although its exact effects are not known for sure, it may act on the neuro-transmitters dopamine and norepinephrine.

Side Effects

Fewer sexual side effects and weight gain are associated with Wellbutrin than other antidepressants.  There are also fewer reports of blurred vision, dry mouth, indigestion, constipation, cardiac problems, and orthostatic hypotension (low blood pressure occurring after standing up). 

However, Wellbutrin has also been linked to the following side effects:

Seizures (see below for drug interaction warnings), Restlessness, Insomnia, Headache or worsening of preexisting migraine conditions, Tremor, Dry Mouth, Agitation, Confusion, Rapid Heartbeat, Hyperactivity, Dizziness, Nausea, Menstrual Complaints, Rash

Because of the risk of seizure, the approval of Wellbutrin was temporarily delayed to examine this risk and since it has been on the market, there have been numerous lawsuits filed against the manufacturer by patients and their families as the result of these dangerous side effects.

Drug Interaction Warnings:

1. Zyban - they contain the same active ingredient, which could cause seizures if too much is taken.
2. Anticonvulsant medications Dilantin (phenytoin), Tegretol (carbamazepine), or phenobarbital
3. Ulcer medication Tagamet (cimetidine)
4. Monoamine oxidase inhibitors (MAOIs).
5. Withdrawal from alcohol or some street drugs while taking Wellbutrin can increase the chance of having seizure.

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